Zoetis BANAMINE
By Zoetis
Last reviewed: January 2024
BANAMINE (flunixin meglumine) is Zoetis's non-steroidal anti-inflammatory drug (NSAID) for cattle, providing relief from pain, fever, and inflammation. As the m
What is BANAMINE?
BANAMINE contains flunixin meglumine, a potent non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase enzymes responsible for prostaglandin synthesis. By blocking prostaglandins, BANAMINE reduces:
Mechanism of Action
Flunixin works by inhibiting cyclooxygenase (COX) enzymes:
Primary Indications in Cattle
Acute Bovine Respiratory Disease (BRD):
Reduces fever and inflammation, improves appetite and attitude, supports antibiotic therapy effectiveness.
Acute Mastitis (Endotoxemia):
Critical for coliform mastitis where endotoxin release causes systemic illness. BANAMINE helps maintain blood pressure, reduce fever, and prevent shock.
Acute Bovine Diarrhea:
Reduces gut inflammation and supports recovery from enteric disease.
Post-Surgical Pain:
Provides analgesia following dehorning, castration, and other procedures.
Dosing and Administration
Key Features
- Potent NSAID: Flunixin meglumine for effective pain and fever control
- Anti-Endotoxic: Unique among NSAIDs for supporting cattle in endotoxemia
- Rapid Onset: IV administration provides relief within 15-30 minutes
- Flexible Dosing: Can repeat for up to 3 days if needed
- Well-Tolerated: Established safety profile in cattle
Advanced Features
- Multiple Formulations: Injectable and transdermal (pour-on) available
- Combination Therapy: Compatible with antibiotics and other treatments
- Cardiovascular Support: Helps maintain blood pressure in shock
- Appetite Improvement: Reduced fever and pain promotes eating
- Endotoxin Binding: Some evidence of direct endotoxin effects
Ideal For
Competitive Advantages
What sets BANAMINE apart from alternatives:
- BANAMINE advantages: 1. **Gold Standard NSAID**: Most prescribed flunixin product in cattle 2. **Anti-Endotoxic Properties**: Critical for coliform mastitis treatment 3. **Rapid IV Onset**: Fast relief when time matters 4. **Zoetis Quality**: Consistent potency and purity 5. **Established Protocols**: Decades of clinical experience 6. **Multiple Formulations**: Injectable and transdermal options
Pricing Information
Here is the pricing information for BANAMINE:
Pros & Considerations
- Highly effective fever and pain control
- Critical for endotoxemia support
- Rapid onset when given IV
- Well-established safety profile
- Multiple formulation options
- Essential tool for cattle practice
- Prescription product requiring VCPR
- Milk and slaughter withdrawal periods
- Risk of injection site lesions with IM (prefer IV)
- Can mask fever—may delay recognizing treatment failure
- GI toxicity possible with prolonged or excessive use
- Not for use in calves intended for veal
Implementation & Setup
How to implement BANAMINE on your dairy operation:
Training & Support
Training and support options available for BANAMINE:
Evaluation Questions
Key questions to consider when evaluating BANAMINE:
- 1. What is our current protocol for treating toxic mastitis? 2. Do we have BANAMINE stocked and accessible? 3. What is our withdrawal tracking process? 4. Are personnel trained on IV administration technique? 5. When do we call the veterinarian vs. treat on-farm? 6. How do we document BANAMINE treatments? 7. What other NSAIDs are we using and why?