Zoetis Draxxin (Tulathromycin)
By Zoetis
Last reviewed: December 2025
Draxxin is a long-acting macrolide antibiotic for BRD treatment and control, providing extended therapy from a single injection.
Overview
Draxxin (tulathromycin) is a single-dose injectable macrolide antibiotic providing extended antibiotic therapy for bovine respiratory disease from one injection.
Extended Action
Pharmacokinetics
Tulathromycin is designed for:
Approved Indications
BRD Treatment
Treatment of bovine respiratory disease associated with:
BRD Control
Control of respiratory disease in cattle at high risk.
Foot Rot
Treatment of interdigital necrobacillosis.
Dosage and Administration
Dose
2.5 mg/kg body weight (1.1 mL per 100 lbs)
Route
Subcutaneous injection in the neck
Withdrawal
Clinical Benefits
One-Time Treatment
Broad Spectrum
Coverage of major BRD pathogens including Mycoplasma bovis.
Responsible Use
Veterinary Prescription
Required under valid VCPR.
Documentation
Maintain complete treatment records.
Resistance Management
Use antibiotics judiciously to preserve effectiveness.
Key Features
- Extended Duration: Single injection provides prolonged therapeutic activity
- Lung Concentration: Accumulates in respiratory tissue where needed
- Single Injection: Reduces handling and stress
- Treatment and Control: Approved for both clinical treatment and metaphylaxis
- Broad BRD Spectrum: Active against Mannheimia, Pasteurella, Histophilus, and Mycoplasma
- Proven Efficacy: Extensive field experience and research support
Ideal For
Farm Types: Dairy heifer operations, Calf ranches, Feedlots, Backgrounding operations
Pricing Information
Here is the pricing information for Draxxin (Tulathromycin):
Long-acting macrolide antibiotic (tulathromycin) for BRD. Single-dose treatment.
Pricing Model: Per-bottle prescription pricing
Single subcutaneous injection provides extended therapy. Veterinary prescription required. Zoetis product.
Pros & Considerations
- True single-dose therapy for BRD
- Extended duration of action
- Concentrates in lung tissue
- Flexible treatment and control claims
- Extensive efficacy documentation
- Widely available and familiar to veterinarians
- Prescription product requiring veterinary oversight
- Premium pricing compared to older antibiotics
- Withdrawal periods must be observed
- Not all animals respond despite proper treatment
- Antimicrobial stewardship considerations
Evaluation Questions
Key questions to consider when evaluating Draxxin (Tulathromycin):
- What is your current BRD incidence rate?
- What treatment products are you currently using?
- What treatment outcomes are you achieving?
- Is single-injection therapy important for your operation?
- Do you have high-risk cattle that might benefit from metaphylaxis?
- What is your veterinary relationship for prescription products?
- What withdrawal periods are compatible with your marketing?
- Are you tracking treatment response rates?