Zoetis Excenel RTU EZ
By Zoetis
Last reviewed: December 2025
Excenel RTU EZ is a ready-to-use ceftiofur injection for treating bovine respiratory disease and foot rot, with convenient no-mixing formulation.
Overview
Excenel RTU EZ (ceftiofur hydrochloride) is a ready-to-use injectable antibiotic for treating bacterial diseases in cattle, particularly bovine respiratory disease complex (BRD) and foot rot.
Approved Indications
Bovine Respiratory Disease
Treatment of BRD associated with:
Acute Foot Rot
Treatment of interdigital necrobacillosis (foot rot) caused by:
Dosage
BRD
1.1-2.2 mg/kg body weight daily for 3-5 days.
Foot Rot
1.1-2.2 mg/kg body weight daily for 3 days.
Administration
Convenient Features
Ready-to-Use
Withdrawal Times
Treatment Protocols
Work with your veterinarian to establish:
Responsible Use
Prescription Required
Valid VCPR required for all antibiotic use.
Record Keeping
Document all treatments including:
Key Features
- Ready-To-Use: No reconstitution needed, reducing preparation time and errors
- Room Temperature Storage: Stable without refrigeration for convenient storage
- Broad-Spectrum Activity: Effective against gram-negative and gram-positive pathogens
- Multiple Indications: BRD, foot rot, and metritis treatment
- Zero Milk Discard: No milk withdrawal in lactating dairy cattle (check current label)
- Established Safety: Well-characterized safety profile
Ideal For
Farm Types: Dairy operations, Beef cattle operations, Calf ranches, Stocker operations
Pricing Information
Here is the pricing information for Excenel RTU EZ:
Extended-release ceftiofur for BRD treatment. Single injection, extended action.
Pricing Model: Per-bottle prescription pricing
Veterinary prescription required. Zoetis product.
Pros & Considerations
- Convenient ready-to-use formulation
- Room temperature stable storage
- Multiple disease indications
- Favorable milk withdrawal profile
- Well-established efficacy
- Easy to administer
- Prescription product requiring veterinary oversight
- Multiple daily injections may be required for some conditions
- Premium pricing compared to generic options
- Antimicrobial stewardship considerations for cephalosporins
- Meat withdrawal period applies
Evaluation Questions
Key questions to consider when evaluating Excenel RTU EZ:
- What conditions do you most frequently treat?
- Is milk withdrawal an important consideration?
- Do you have refrigeration available for product storage?
- What cephalosporin products are you currently using?
- What are your treatment outcomes currently?
- Do you have a veterinary relationship for prescriptions?
- What treatment convenience factors matter to you?
- Are you following antimicrobial stewardship guidelines?