What is the price of Inforce 3?

Contact the vendor for pricing details.

How much does Inforce 3 cost?

Contact the vendor for pricing details.

What are the main features of Inforce 3?

Key features of Inforce 3 include: Intranasal Delivery, Three-Way Viral Coverage, Early Age Use, Rapid Onset, Maternal Antibody Compatible.

What are the advantages of Inforce 3?

Inforce 3 strengths include: Works in very young calves (1 week+), Overcomes maternal antibody interference, Rapid local immunity development, No injection sites.

What are the limitations of Inforce 3?

Inforce 3 considerations include: Does not include BVD (need injectable for complete coverage), Must use within 1 hour of reconstitution, Some calves resist nasal restraint.

1. At what age are we currently vaccinating calves for respiratory disease? 2. What is our pre-weaning respiratory disease incidence? 3. Are we seeing vaccine failures potentially due to maternal antibody interference? 4. What respiratory viruses are causing disease (diagnostic history)? 5. Can we incorporate intranasal vaccination into calf processing workflow? 6. Are replacement heifers having injection site reactions affecting value? 7. What is the current cost per calf for respiratory vaccination?

Contact the vendor for detailed information about this topic.

Zoetis Inforce 3

By Zoetis

Last reviewed: January 2024

Inforce 3 is Zoetis's intranasal respiratory vaccine for cattle, providing rapid mucosal immunity against IBR, BRSV, and PI3 viruses. Administered as a 1 mL spr

What is Inforce 3?

Inforce 3 is a modified-live virus (MLV) intranasal vaccine containing:

Infectious Bovine Rhinotracheitis (IBR) virus

Bovine Respiratory Syncytial Virus (BRSV)

Parainfluenza Type 3 (PI3) virus

Unlike injectable vaccines, Inforce 3 is sprayed directly into the nasal passage, stimulating local mucosal immunity where respiratory infections begin.

Intranasal Advantage

The intranasal route provides unique benefits:

Rapid Local Immunity: Protection develops at the respiratory mucosa within days

Maternal Antibody Override: Works even in calves with high colostral antibodies

Early Life Use: Licensed for calves as young as 1 week old

First-Line Defense: IgA antibodies at mucosa block viral entry

How Mucosal Immunity Works

When vaccine virus contacts nasal mucosa:

Local immune cells recognize viral antigens

IgA antibody production begins at mucosal surface

Memory cells populate the respiratory tract

Upon challenge, rapid local response neutralizes virus before systemic infection

Young Calf Application

Inforce 3 is particularly valuable for dairy calf programs:

Can be given at birth/first week while maternal antibodies are still high

Protects during the high-risk pre-weaning period

Works alongside colostrum-derived passive immunity

No injection site reaction in valuable replacement heifers

Key Features

Intranasal Delivery: 1 mL spray into one nostril for complete dose
Three-Way Viral Coverage: IBR, BRSV, PI3 protection
Early Age Use: Licensed as early as 1 week of age
Rapid Onset: Local immunity develops within days
Maternal Antibody Compatible: Works despite passive antibodies

Advanced Features

Mucosal IgA Response: Local antibodies at site of infection
Modified-Live Potency: Strong, long-lasting immune memory
Needle-Free Administration: No injection site reactions
Stress Timing Flexibility: Can be given near stressful events
Booster Flexibility: Single intranasal dose or boost with injectable later

Ideal For

Competitive Advantages

What sets Inforce 3 apart from alternatives:

Inforce 3 advantages: 1. **Earliest Protection**: Can vaccinate from 1 week of age 2. **Maternal Antibody Solution**: Works when injectables are blocked 3. **Speed of Protection**: Faster onset than injectable vaccines 4. **No Injection Sites**: Important for replacement heifer programs 5. **Easy Administration**: Simple nasal spray application 6. **Proven Technology**: Established intranasal platform from Zoetis

Pricing Information

Here is the pricing information for Inforce 3:

Pros & Considerations

Advantages:

Works in very young calves (1 week+)
Overcomes maternal antibody interference
Rapid local immunity development
No injection sites
Easy to administer
Establishes mucosal immunity at infection site

Considerations:

Does not include BVD (need injectable for complete coverage)
Must use within 1 hour of reconstitution
Some calves resist nasal restraint
Sneezing can aerosolize vaccine (avoid in sick calves)
Storage at 2-7°C required

Implementation & Setup

How to implement Inforce 3 on your dairy operation:

Training & Support

Training and support options available for Inforce 3:

Evaluation Questions

Key questions to consider when evaluating Inforce 3:

1. At what age are we currently vaccinating calves for respiratory disease? 2. What is our pre-weaning respiratory disease incidence? 3. Are we seeing vaccine failures potentially due to maternal antibody interference? 4. What respiratory viruses are causing disease (diagnostic history)? 5. Can we incorporate intranasal vaccination into calf processing workflow? 6. Are replacement heifers having injection site reactions affecting value? 7. What is the current cost per calf for respiratory vaccination?