Zoetis Lutalyse (Dinoprost)
By Zoetis
Last reviewed: December 2025
Prostaglandin F2alpha injection used for estrus synchronization, pregnancy termination, and treatment of reproductive conditions in cattle.
Lutalyse (dinoprost tromethamine) is a synthetic prostaglandin F2alpha used in dairy cattle reproductive management. It is one of the most commonly used reproductive pharmaceuticals in the dairy industry.
Primary uses include estrus synchronization for AI programs, pregnancy termination, pyometra treatment, and mummified fetus expulsion. The product causes regression of the corpus luteum, bringing cows into estrus 2-5 days after injection.
Lutalyse is a prescription product requiring veterinary oversight. It is used as part of synchronization protocols like Ovsynch, Presynch, or Double-Ovsynch. Proper handling and administration techniques are essential.
Key Features
- Estrus Synchronization: Bring cows into heat
- Protocol Component: Used in timed AI programs
- Pregnancy Termination: When medically indicated
- Pyometra Treatment: Treat uterine infections
- Proven Product: Decades of use
Advanced Features
- Flexible Protocols: Multiple program options
- Combination Programs: Use with GnRH products
- Fertility Programs: Resynchronization options
- Veterinary Support: Protocol design assistance
Ideal For
Farm Types: All dairy operations using AI
Competitive Advantages
What sets Lutalyse (Dinoprost) apart from alternatives:
- Industry standard product
- Proven efficacy over decades
- Well-understood pharmacology
- Multiple protocol options
- Wide availability
Pricing Information
Here is the pricing information for Lutalyse (Dinoprost):
Sold in multi-dose bottles through veterinary channels
Pricing Model: per-dose
Prescription product; pricing through veterinary distributors.
Pros & Considerations
- Industry standard prostaglandin for reproduction
- Causes luteolysis for estrus synchronization
- Used in OvSynch and other breeding protocols
- Proven track record over decades
- Relatively economical per dose
- Prescription product requiring veterinary relationship
- Strict handling precautions needed (causes abortion)
- Must have functional CL for efficacy
- Multiple formulations require attention to dosing
- Human safety concerns during handling
Implementation & Setup
How to implement Lutalyse (Dinoprost) on your dairy operation:
Implementation Timeline: Available through veterinary distributors
Training & Support
Training and support options available for Lutalyse (Dinoprost):
Support Channels:
Evaluation Questions
Key questions to consider when evaluating Lutalyse (Dinoprost):
- What synchronization protocol are you using?
- Do you have veterinary oversight?
- What is your breeding program structure?
- How do you handle and store pharmaceuticals?
- Are staff trained on proper administration?