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First Defense Calf Health Tri-Shield Gel Tube

By First Defense Calf Health

Last reviewed: February 2026

Tri-Shield Gel Tube by First Defense Calf Health: an independent product guide from the Therio Dairy Directory. Compare features, pricing, and alternatives...

Key Features

  • Triple Pathogen Protection: The only veterinary biologic providing guaranteed antibody levels against K99+ E. coli, bovine coronavirus, and bovine rotavirus in a single dose.
  • Proven Rotavirus Shedding Reduction: Third-party research (Skidmore et al.) demonstrated significant reduction in rotavirus shedding, protecting not just the treated calf but reducing environmental pathogen load for the entire herd.
  • VLP-Enhanced Rotavirus Antibodies: Rotavirus antibodies produced using proprietary virus-like particle (VLP) technology developed in collaboration with Baylor College of Medicine, delivering higher antibody titers than traditional vaccine approaches.
  • Single-Dose Gel Tube Administration: Easy oral gel tube format allows quick administration at birth. One dose provides complete triple-pathogen protection.
  • USDA Approved Biologic: Approved by the USDA Veterinary Center for Biologics, meeting the same rigorous efficacy standards required for scours vaccines.
  • OMRI Listed for Organic: Certified for use in organic dairy and beef operations.

Advanced Features

  • Environmental Herd Protection: By reducing rotavirus shedding, Tri-Shield helps lower pathogen levels in the calf barn environment, providing a protective benefit beyond individual calf treatment.
  • Potency-Tested Consistency: Every dose is potency-tested before release, ensuring consistent protection calf-to-calf and eliminating the 20-30% vaccine response failure rate.
  • Complementary to Colostrum Management: Designed to work alongside maternal colostrum feeding, providing targeted pathogen-specific antibodies that complement the broad-spectrum protection of quality colostrum.

Ideal For

Farm Types: Dairy farms, Beef cow-calf operations, Calf ranches, Organic dairy operations, Custom calf raising facilities

Pricing Information

Here is the pricing information for Tri-Shield Gel Tube:

Contact your First Defense representative or authorized veterinary distributor for current pricing.

Pricing Model: Per-dose pricing through veterinary distributors

Tri-Shield is sold through authorized veterinary distributors and First Defense representatives. As the only triple-pathogen biologic, it is positioned at a premium compared to dual-pathogen options. Pricing varies by distributor and volume.

Pros & Considerations

Advantages:
  • Only product providing guaranteed triple-pathogen immunity (E. coli, coronavirus, rotavirus)
  • Proven rotavirus shedding reduction benefits entire herd
  • VLP technology delivers higher rotavirus antibody levels
  • USDA-approved veterinary biologic with potency-tested doses
  • OMRI listed for organic operations
  • Immediate immunity without vaccine response variability
Considerations:
  • Requires refrigeration
  • Higher cost per dose than dual-pathogen options
  • Must be administered within first 24 hours of life for optimal results

About First Defense Calf Health

Learn more about First Defense Calf Health and their complete product lineup on their company profile page.

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