First Defense Calf Health Tri-Shield Gel Tube
Last reviewed: February 2026
Compare Tri-Shield Gel Tube pricing, features, and alternatives. Learn how First Defense Calf Health's Calf Health solution stacks up for dairy operations.
Key Features
- Triple Pathogen Protection: The only veterinary biologic providing guaranteed antibody levels against K99+ E. coli, bovine coronavirus, and bovine rotavirus in a single dose.
- Proven Rotavirus Shedding Reduction: Third-party research (Skidmore et al.) demonstrated significant reduction in rotavirus shedding, protecting not just the treated calf but reducing environmental pathogen load for the entire herd.
- VLP-Enhanced Rotavirus Antibodies: Rotavirus antibodies produced using proprietary virus-like particle (VLP) technology developed in collaboration with Baylor College of Medicine, delivering higher antibody titers than traditional vaccine approaches.
- Single-Dose Gel Tube Administration: Easy oral gel tube format allows quick administration at birth. One dose provides complete triple-pathogen protection.
- USDA Approved Biologic: Approved by the USDA Veterinary Center for Biologics, meeting the same rigorous efficacy standards required for scours vaccines.
- OMRI Listed for Organic: Certified for use in organic dairy and beef operations.
Advanced Features
- Environmental Herd Protection: By reducing rotavirus shedding, Tri-Shield helps lower pathogen levels in the calf barn environment, providing a protective benefit beyond individual calf treatment.
- Potency-Tested Consistency: Every dose is potency-tested before release, ensuring consistent protection calf-to-calf and eliminating the 20-30% vaccine response failure rate.
- Complementary to Colostrum Management: Designed to work alongside maternal colostrum feeding, providing targeted pathogen-specific antibodies that complement the broad-spectrum protection of quality colostrum.
Ideal For
Farm Types: Dairy farms, Beef cow-calf operations, Calf ranches, Organic dairy operations, Custom calf raising facilities
Pricing Information
Here is the pricing information for Tri-Shield Gel Tube:
Contact your First Defense representative or authorized veterinary distributor for current pricing.
Pricing Model: Per-dose pricing through veterinary distributors
Tri-Shield is sold through authorized veterinary distributors and First Defense representatives. As the only triple-pathogen biologic, it is positioned at a premium compared to dual-pathogen options. Pricing varies by distributor and volume.
Pros & Considerations
- Only product providing guaranteed triple-pathogen immunity (E. coli, coronavirus, rotavirus)
- Proven rotavirus shedding reduction benefits entire herd
- VLP technology delivers higher rotavirus antibody levels
- USDA-approved veterinary biologic with potency-tested doses
- OMRI listed for organic operations
- Immediate immunity without vaccine response variability
- Requires refrigeration
- Higher cost per dose than dual-pathogen options
- Must be administered within first 24 hours of life for optimal results