Zoetis LUTALYSE HighCon
By Zoetis
Last reviewed: January 2024
LUTALYSE HighCon Injection is Zoetis's concentrated prostaglandin F2α (dinoprost tromethamine) formulation that delivers the same 25 mg active dose as original
What is LUTALYSE HighCon?
LUTALYSE HighCon (dinoprost tromethamine) is a concentrated prostaglandin F2α injection containing 12.5 mg/mL of active ingredient, compared to 5 mg/mL in standard LUTALYSE. Both formulations deliver the same 25 mg labeled dose, but LUTALYSE HighCon achieves this in just 2 mL rather than 5 mL.
How Prostaglandins Work
Prostaglandin F2α (PGF2α) is a natural hormone produced by the uterus that causes regression (destruction) of the corpus luteum (CL). In reproductive management:
Why High Concentration Matters
The 2 mL dose volume offers practical advantages:
Faster Handling: Smaller injection delivered more quickly—critical for large groups
Reduced Reactions: Less volume means smaller injection site response
More Doses Per Bottle: 100-mL bottle = 50 doses (vs. 20 doses of standard)
Lower Shipping Cost: Concentrate ships more efficiently
Easier Storage: Less refrigerator/cabinet space needed
Labeled Indications
Key Features
- High Concentration Formula: 12.5 mg/mL delivers full 25 mg dose in 2 mL
- Same Proven Efficacy: Bioequivalent to standard LUTALYSE—identical results
- IM or SQ Administration: Labeled for both intramuscular and subcutaneous injection
- Extended Bottle Life: 50 doses per 100-mL bottle reduces waste
- Room Temperature Stable: Store at controlled room temperature (20-25°C)
Advanced Features
- Natural Prostaglandin: Dinoprost tromethamine is the salt of natural PGF2α
- Rapid Absorption: Quick uptake from injection site for reliable timing
- Protocol Versatility: Works in all standard sync protocols (Ovsynch, CO-Synch, Presynch, etc.)
- Residue-Tested: Established withdrawal time for beef and dairy (0 days milk, 0 days meat)
Ideal For
Competitive Advantages
What sets LUTALYSE HighCon apart from alternatives:
- LUTALYSE HighCon advantages: 1. **Efficiency**: 60% less injection volume saves time on every cow 2. **Economics**: More doses per bottle, lower cost per treatment 3. **Cattle Comfort**: Smaller injection volume reduces tissue reaction 4. **Zoetis Quality**: Same trusted LUTALYSE brand, concentrated formulation 5. **Protocol Proven**: Compatible with all established synchronization programs 6. **Zero Withdrawal**: No milk or meat withholding period
Pricing Information
Here is the pricing information for LUTALYSE HighCon:
Pros & Considerations
- Same proven efficacy as original LUTALYSE
- 60% smaller injection volume
- More doses per bottle
- Zero milk and meat withdrawal
- Compatible with all sync protocols
- Faster handling in large groups
- Requires accurate low-volume dosing (2 mL)
- Must not be used in pregnant cattle (causes abortion)
- Human safety precautions (wear gloves, especially pregnant women/asthmatics)
- No extra-label use in minor species without VCPR
- Can cause sweating, increased respiration in treated cattle
Implementation & Setup
How to implement LUTALYSE HighCon on your dairy operation:
Training & Support
Training and support options available for LUTALYSE HighCon:
Evaluation Questions
Key questions to consider when evaluating LUTALYSE HighCon:
- 1. What is our current prostaglandin product and protocol? 2. How many cows/heifers do we inject at typical reproductive events? 3. Are we experiencing injection site reactions with current PG? 4. What is our time constraint for processing groups through the chute? 5. Do we have accurate 2 mL dosing capability (appropriate syringes)? 6. Are handlers trained on proper injection technique and safety? 7. What is our per-dose prostaglandin cost currently? 8. How do we track PG treatments and breeding dates?