Zoetis Pirsue (Pirlimycin)
By Zoetis
Last reviewed: December 2025
Pirsue offers targeted gram-positive mastitis treatment with pirlimycin, featuring excellent tissue penetration and a short milk withdrawal period.
Overview
Pirsue (pirlimycin hydrochloride) is a lincosamide antibiotic approved for treating clinical and subclinical mastitis caused by susceptible gram-positive organisms in lactating dairy cows.
Spectrum of Activity
Pirlimycin is highly effective against:
Pharmacological Advantages
Excellent Penetration
Pirlimycin achieves high concentrations in mammary tissue, including areas with chronic infections.
Lipophilic Properties
Fat-soluble nature enables penetration into biofilms and abscess walls.
Dosage Regimen
Extended Treatment Protocol
Withdrawal Periods
Clinical Applications
Subclinical Mastitis
Often used for treating high-SCC cows during lactation to reduce infection prevalence.
Chronic Staph aureus
Extended protocol may improve cure rates for difficult chronic infections.
Blitz Therapy Programs
Some farms use Pirsue in coordinated treatment of all infected cows to reduce infection reservoir.
Treatment Records
Maintain complete treatment records including:
Response Monitoring
Evaluate treatment success through:
Key Features
- Gram-Positive Focus: Targets Strep and Staph species
- Lincosamide Class: Different mode of action than beta-lactams
- Good Tissue Penetration: Effective distribution in mammary gland
- Ready-to-Use: Convenient syringe format
- Subclinical Efficacy: Effective for elevated SCC cows
Advanced Features
- Extended Therapy: Can be used for multi-day treatment
- Blitz Therapy: Option for herd-level interventions
Ideal For
Farm Types: Dairy farms, All housing types
Competitive Advantages
What sets Pirsue (Pirlimycin) apart from alternatives:
- Excellent gram-positive activity
- Good for subclinical cases
- Well-studied efficacy
- Different antibiotic class for rotation
Pricing Information
Here is the pricing information for Pirsue (Pirlimycin):
Intramammary antibiotic for lactating cow mastitis treatment.
Pricing Model: Per-tube mastitis treatment
Pirsue (pirlimycin) by Zoetis. Prescription required. Effective against Gram-positive mastitis pathogens.
Pros & Considerations
- Effective against Staph aureus and Strep species
- FDA approved for mastitis treatment
- Specific spectrum reduces broad resistance concerns
- Established treatment protocols
- Targeted therapy for gram-positive infections
- Prescription product
- Limited spectrum - not for gram-negatives
- Milk and meat withdrawal required
- Works best with culture confirmation
Implementation & Setup
How to implement Pirsue (Pirlimycin) on your dairy operation:
Implementation Timeline: Used as needed for clinical cases
Training & Support
Training and support options available for Pirsue (Pirlimycin):
Support Channels:
Evaluation Questions
Key questions to consider when evaluating Pirsue (Pirlimycin):
- What gram-positive pathogens are common?
- Do you use culture-based treatment?
- What is your subclinical mastitis rate?
- Are you rotating antibiotic classes?