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Zoetis SPECTRAMAST DC

By Zoetis

Last reviewed: January 2024

SPECTRAMAST DC (ceftiofur hydrochloride) is Zoetis's dry cow intramammary antibiotic for treating existing subclinical mastitis infections at dry-off and preven

What is SPECTRAMAST DC?

SPECTRAMAST DC is an intramammary infusion containing ceftiofur hydrochloride, a third-generation cephalosporin antibiotic, formulated specifically for dry cow therapy. Unlike lactating cow treatments, SPECTRAMAST DC is designed to persist in the udder throughout the dry period, treating existing infections while preventing new ones from establishing.

Why Dry Cow Therapy Matters

The dry period is paradoxically both a healing opportunity and a high-risk time:

Healing Opportunity:

  • No milk removal means antibiotics aren't diluted daily
  • Extended drug contact time improves cure rates
  • Teat end damage from milking can heal
  • Immune system can focus on clearing infections
  • High-Risk Period:

  • Teat sphincter remains open for 1-2 weeks after last milking
  • Natural keratin plug may not form completely in all cows
  • Coliform infection risk is 4× higher than during lactation
  • New infections during dry period often persist into next lactation
  • Broad-Spectrum Coverage

    SPECTRAMAST DC is effective against the major mastitis pathogens:

    Gram-Positive:

  • Staphylococcus aureus (including some penicillin-resistant strains)
  • Streptococcus dysgalactiae
  • Streptococcus uberis
  • Streptococcus agalactiae
  • Coagulase-negative staphylococci
  • Gram-Negative:

  • Escherichia coli
  • Klebsiella species
  • Administration Protocol

    At dry-off (after final milking of lactation):

  • Clean and disinfect each teat thoroughly
  • Infuse contents of one SPECTRAMAST DC tube per quarter
  • Massage upward to distribute product in gland
  • Apply teat sealant (ORBESEAL) if using blanket dry cow therapy
  • Move cow to dry cow housing—do not milk again
  • Key Features

    • Third-Generation Cephalosporin: Ceftiofur provides excellent gram-positive and gram-negative coverage
    • Extended Persistence: Formulated for sustained activity throughout dry period
    • Single-Tube Administration: One tube per quarter at dry-off—no repeat treatments needed
    • Convenient Packaging: Individual tubes with attached cannula for hygienic infusion
    • Proven Cure Rates: Clinical trials demonstrate high bacteriological cure rates for major pathogens

    Advanced Features

    • Synergy with Teat Sealant: Often used in combination with ORBESEAL for complete dry cow protocol
    • Beta-Lactamase Stability: Ceftiofur resists degradation by penicillin-resistant bacteria
    • Low Residue Risk: When used according to label, milk withdrawal is managed by dry period length
    • Treatment Documentation: Clear labeling supports treatment record compliance

    Ideal For

    Competitive Advantages

    What sets SPECTRAMAST DC apart from alternatives:

    • SPECTRAMAST DC advantages over other dry cow products: 1. **Broad Spectrum**: Single product covers gram-positive AND gram-negative pathogens 2. **Cephalosporin Class**: Different mechanism than penicillins for resistant organisms 3. **Zoetis Quality**: Consistent manufacturing and potency 4. **Program Integration**: Part of complete dry cow protocol with ORBESEAL and ENVIRACOR J-5 5. **Established Track Record**: Years of proven field performance

    Pricing Information

    Here is the pricing information for SPECTRAMAST DC:

    Pros & Considerations

    Advantages:
    • Broad-spectrum coverage including gram-negatives
    • Single-treatment convenience at dry-off
    • Well-proven cure rates in clinical trials
    • Compatible with teat sealant protocols
    • Established Zoetis quality and support
    Considerations:
    • Prescription product requiring VCPR
    • Not for use in lactating cows (different product: SPECTRAMAST LC)
    • Antibiotic use—not compatible with organic certification
    • Requires proper dry period length for withdrawal compliance
    • Must ensure cows are not milked after treatment

    Implementation & Setup

    How to implement SPECTRAMAST DC on your dairy operation:

    Training & Support

    Training and support options available for SPECTRAMAST DC:

    Evaluation Questions

    Key questions to consider when evaluating SPECTRAMAST DC:

    1. 1. What is our current dry cow therapy protocol (blanket vs. selective)? 2. What percentage of fresh cows develop mastitis in first 30 DIM? 3. What are our SCC trends from dry-off to fresh? 4. What pathogens are causing mastitis in our herd (culture data)? 5. Are we using teat sealant in combination with antibiotics? 6. What is our dry period length (adequate for milk withdrawal)? 7. Do we have staff properly trained on intramammary infusion technique? 8. How are dry cow treatments documented in our records?

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    About Zoetis

    Learn more about Zoetis and their complete product lineup on their company profile page.

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